Trientine hydrochloride specifically is N,N'-bis (2-aminoethyl)-1, 2-ethanediamine dihydrochloride. This agent comes as a white to pale yellow crystalline hygroscopic powder. It is freely soluble in the water, soluble in the methanol, slightly soluble in ethanol, and insoluble in chloroform and ether.
Trientine HCL is a chelating compound used for the removal of excess copper from the body. It is available as 250 mg capsules for oral use. The trientine 250 mg capsules contain gelatin, iron oxides, stearic acid, and titanium dioxide as inactive ingredients.
Approval: Syprine is manufactured by Valeant Pharmaceuticals International, Inc. On 8'th November 1985, Syprine (Trientine HCL) was approved by the USFDA.
Dosage Form: The trientine hydrochloride 250 mg comes in the form of capsules generically and under the brand name Syprine. Always take trientine capsules exactly as your doctor has told you.
In adult patients of all ages, including the elderly, the usual daily dose is between 4 & 8 capsules per day (total of 0.67 -1.34 g trientine base), to be administered orally. This usual daily dose will be divided into 2-4 smaller doses to be administered during the day. Your healthcare professional will tell you how many capsules you need to take and how often in a particular day.
Children: The standard dose that you will take is usually lower than for an adult and depends on the age as well as body weight. The usual dose usually varies between 2 & 5 capsules, to be administered orally. This usual dosage will be divided into 2-4 smaller doses to be administered during the day. Your healthcare professional will tell you how many capsules you need to take and how often in a particular day.
Once, starting the treatment, your healthcare professional may adjust the dose based on the response to treatment. The trientine capsules should be swallowed whole with water on an empty stomach, at least 1 hour before meals or 2 hours after meals, and a minimum of 1 hour apart from any other drugs, food, or milk. In case you administer iron supplements, take them a minimum of 2 hours after administering a trientine dose.
Side Effects: The side effects of trientine 250 mg are usually mild and not life-threatening. The commonly reported side effects may include feeling sick (nausea), skin rashes, and itching.
Important Safety Information:
It is not advisable to take Trientine Hydrochloride in case you are allergic to it.
Patients should remain under regular medical supervision the entire time while on treatment with Trientine.
A health specialist should regularly assess to see if patients have iron deficiency anemia. This is specifically crucial for women. A health specialist should also check for free copper in the blood.
Take Trientine on an empty stomach, at least 60 minutes before a meal or 120 minutes after a meal, and at least 60 minutes apart from any other medicine, food, or milk. The capsules of Trientine should be gulped completely with water and should not be chewed or opened.
For the initial month of therapy, take your temperature every night, and report any signs and symptoms such as fever or skin rash to your health specialist.
It is not advisable to take mineral supplements because they may inhibit the absorption of this medicine.
Let your healthcare professional know in case you are pregnant, want to become pregnant, or are a nursing mother.
The following side effects have been noted from a clinical study: iron deficiency and systemic lupus erythematosus (a condition affecting the immune system). In addition, the following side effects have been noted in marketed use: abnormal or uncontrolled muscle contractions, muscle spasm, and myasthenia gravis (an immune disease affecting muscles).
Cost: The trientine price in India may vary depending on the wholesaler or pharmacy and, of course, the brand you choose. The cost of trientine is around $6,433 for a supply of 100 capsules.
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