A brief discussion on Cisatracurium Besylate

Indication: Cisatracurium besylate is approved as an adjunct to the general anesthesia to facilitate tracheal intubation in adults as well as pediatric patients aged 1 month to 12 years; to provide skeletal muscle relaxation in adult patients during surgical procedures or mechanical ventilation in the ICU, and to provide the skeletal muscle relaxation during surgical procedures through infusion in the pediatric patients aged 2 years and older. The cisatracurium besylate should not be considered for rapid sequence endotracheal intubation.

Mechanism of Action: Cisatracurium besylate as an active ingredient belongs to a group of

medicines called "neuromuscular blockers". It works in order to block the effects of one of the body's chemical messengers known as acetylcholine. This chemical messenger is involved in muscle contraction. By relaxing the body's muscles cisatracurium besylate injection makes it easier for you to be kept asleep (under anaesthesia) or sedation.

Dosage and Administered: The cisatracurium besylate is a medication that is administered by injection.

The recommended cisatracurium dose should be administered by an anaesthetist or other highly trained healthcare practitioner, usually during surgery or other medical procedures. The dosage of cisatracurium may vary according to several factors such as the body weight and duration of the procedure.

Adverse Reactions: All medicines can have adverse reactions. Sometimes they're serious. Most of the time they are not. Report your healthcare professional as soon as possible in case you do not feel well after you have received cisatracurium treatment.

It is possible that this medication may cause the following adverse reactions:

• Skin rashes.

• Slow heartbeat.

• Low blood pressure.

• Difficulty breathing.

• Flushing of the face and upper body.

During studies using cisatracurium nimbex less than 1 patient in every 200 treated experienced these adverse reactions.

Assessment:

• Patients should be assessed for their respiratory status continuously throughout the cisatracurium therapy. Use only in order to facilitate intubation or in patients already intubated.

• Patients should be monitored for neuromuscular response with a peripheral nerve stimulator intraoperatively. Paralysis in starting is selective and usually may occur sequentially in: muscles of the mastication, abdominal muscles, limb muscles, muscles of the glottis, intercostal muscles, and the diaphragm. Recovery of the muscle function usually occurs in the reverse order.

• Patients with cisatracurium should be monitored for ECG, heart rate, and BP throughout the administration.

• Patients should be observed for the residual muscle weakness and respiratory distress during the period of recovery.

• Patients should be monitored for the infusion site on a frequent basis. In case signs of tissue irritation or extravasation occur, discontinue and restart in the other vein.

Warning & Precautions:

• Do not use cisatracurium in case you are allergic to it or its any ingredients, or any other muscle relaxant.

• Talk to your healthcare provider prior to having a cisatracurium dose if you have a neuromuscular disease, such as paralysis, muscle-wasting disease, motor neurone disease, or cerebral palsy.

• Inform your doctor before taking this medication in case you have a burn which needs medical treatment.

• In case you're pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your healthcare provider for advice prior to taking cisatracurium ampoule.

• In case you're only staying in the hospital for the day, your healthcare team will tell you how long to wait prior to leaving the hospital or driving a car. It could be dangerous to drive too soon following an operation.

Overdose: Overdoses of cisatracurium infusion may lead to prolonged relaxation of the body's muscles. This can be readily treated, however, this scenario is unlikely to occur because this medication is only administered by an anaesthetist or other highly trained healthcare practitioner who will closely monitor the progress of a patient.

Storage: The cisatracurium injection should be stored between 2°C and 8°C and protected from light. Cisatracurium does not contain any antimicrobial preservative.

The diluted cisatracurium besylate medication is chemically as well as physically stable for the minimum 12 hours, when stored in the polyethylene or polypropylene containers.

Price: The cisatracurium price in India is quite reasonable and may vary depending on the pharmaceutical wholesaler, and brand you choose. The price for cisatracurium is around 705 INR for a supply of vial of 10mL injection.

NOTE: The piece of information provided in this article about "A Brief Discussion On Cisatracurium Besylate" is just for informational purposes and is not served as a substitute for the medical treatment, consultation, diagnosis, of an experienced or qualified healthcare practitioner.